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[MYOCARDIAL INFARCTION IN THE PATIENTS WITH COPD: CAUSES, RISK FACTORS AND PATHOGENICAL LINK (REVIEW)]

I Liverko1, E Abduganiva1

  • 1Republican Specialized Research Practical Medical Center of Phthisiology and Pulmonology, Tashkent, Uzbekistan.

Georgian Medical News
|May 19, 2019
PubMed

Insights

Chronic obstructive pulmonary disease (COPD) and myocardial infarction share common causes. Endothelial dysfunction, inflammation, and coagulation issues link these conditions, predicting severe outcomes.

Area of Science:

  • Cardiology
  • Pulmonology
  • Pathophysiology

Background:

  • Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases frequently coexist.
  • These comorbidities are significant predictors of severe health outcomes.
  • Understanding their interconnectedness is crucial for patient management.

Purpose of the Study:

  • To conduct an analytical review of the complex, multifactorial links between myocardial infarction (MI) and COPD.
  • To elucidate the nature and underlying mechanisms connecting these two prevalent diseases.

Main Methods:

  • Literature review.
  • Analytical analysis of existing research on COPD and MI.
  • Synthesis of pathogenic mechanisms.

Main Results:

  • Identified shared pathogenic mechanisms between COPD and MI.
  • Highlighted the role of endothelial dysfunction in linking the conditions.
  • Emphasized the contribution of chronic systemic inflammation and coagulation/anticoagulation system imbalances.

Conclusions:

  • Endothelial dysfunction, chronic systemic inflammation, and altered coagulation/anticoagulation systems are key common pathogenic mechanisms.
  • These shared pathways contribute to the development of myocardial infarction in patients with COPD.

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