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Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
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Pulpal responses after direct pulp capping with two calcium-silicate cements in a rat model
Panruethai Trongkij1, Supachai Sutimuntanakul1, Puangwan Lapthanasupkul2
1Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University.
Dental Materials Journal
|May 21, 2019
Summary
Bio-MA, a novel pulp capping material containing calcium chloride accelerator, demonstrated biocompatibility comparable to white mineral trioxide aggregate (WMTA). Both materials effectively promoted healing and reparative dentin formation in exposed rat molars.
Area of Science:
- Biomaterials Science
- Dental Pulp Biology
- Regenerative Dentistry
Background:
- Pulp capping aims to preserve pulp vitality and promote healing.
- Calcium-silicate cements are widely used for pulp capping due to their biocompatibility.
- Bio-MA is a novel calcium-silicate cement containing a calcium chloride accelerator.
Purpose of the Study:
- To evaluate the bioactivity and pulp healing potential of Bio-MA compared to white mineral trioxide aggregate (WMTA).
- To assess the inflammatory response and reparative dentin formation following pulp capping with Bio-MA.
Main Methods:
- Mechanically exposed rat molar pulps were capped with either Bio-MA or WMTA.
- Histological examination was performed at 1, 7, and 30 days post-procedure.
- Inflammatory cell infiltration and reparative dentin formation were quantitatively assessed.
Main Results:
- No significant difference in pulpal responses was observed between Bio-MA and WMTA at any time point.
- Mild localized inflammation was noted at 1 day, with partial dentin bridge formation by 7 days.
- Complete tubular dentin bridges and normal pulp appearance were evident at 30 days.
Conclusions:
- Bio-MA, with its calcium chloride accelerator, exhibits comparable biocompatibility and efficacy to WMTA.
- Bio-MA is a viable alternative for pulp capping, promoting significant pulp repair and dentin bridge formation.
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