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Decellularised porcine peritoneum as a tendon protector sheet.
Héctor Capella-Monsonís1,2, Jack Kelly3, Stephen Kearns3
1Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Biomedical Materials (Bristol, England)
|May 21, 2019
Summary
Decellularised porcine peritoneum (XenoMEM) shows promise as a tendon protector sheet, outperforming a commercial product in mechanical strength, friction, and biocompatibility. This biomaterial offers a superior option for tendon tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Tissue grafts are the gold standard for tendon repair due to their biomimicry and mechanical integrity.
- Developing effective tendon protector sheets is crucial for enhancing healing and preventing adhesion post-surgery.
Purpose of the Study:
- To evaluate decellularised porcine peritoneum (XenoMEM) as a tendon protector sheet.
- To compare XenoMEM's properties against a commercially available product, TenoGlide®.
Main Methods:
- Assessed cross-linking ratio, mechanical properties, and coefficient of friction.
- Evaluated cytocompatibility with human tenocytes and immune response with macrophages.
- Utilized comparative analysis between XenoMEM and TenoGlide®.
Main Results:
- XenoMEM demonstrated a lower cross-linking ratio and superior mechanical properties compared to TenoGlide®.
- XenoMEM exhibited a lower coefficient of friction and enhanced cytocompatibility with tenocytes.
- XenoMEM showed a reduced immune response when interacting with macrophages.
Conclusions:
- Decellularised porcine peritoneum (XenoMEM) possesses advantageous properties for tendon protection.
- XenoMEM presents a viable and potentially superior alternative to existing commercial products for tendon tissue engineering.
- Further research supports XenoMEM's clinical application in tendon repair and regeneration.
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