Crystal structure of memantine-carb-oxy-borane

Area of Science:

• Medicinal Chemistry
• Crystallography
• Materials Science

Background:

• Memantine is a drug used to treat Alzheimer's disease.
• Understanding the structural properties of memantine derivatives is crucial for developing new therapeutic agents.
• Adamantane derivatives have shown promise in various pharmaceutical applications.

Purpose of the Study:

• To synthesize and characterize a new compound derived from memantine.
• To determine the crystal structure of the synthesized compound.
• To investigate the intermolecular interactions and structural features of the memantine derivative.

Main Methods:

• Chemical synthesis of the target compound.
• Single-crystal X-ray diffraction analysis.
• Crystallographic data processing and structure refinement using PLATON software.

Main Results:

• The synthesis of the title compound, C13H24BNO2, derived from memantine, was successful.
• The crystal structure revealed an almost planar C-N-B-CO2 unit.
• Carboxylic acid inversion dimers and [001] chains formed via hydrogen bonding were observed in the crystal structure.

Conclusions:

• The study provides detailed structural insights into a novel memantine derivative.
• The observed hydrogen bonding network influences the crystal packing and molecular assembly.
• This research contributes to the understanding of structure-activity relationships for potential therapeutic agents.