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[Atopic eczema and microbiome].

M Reiger, V Schwierzeck, C Traidl-Hoffmann^1,2,3

¹Lehrstuhl und Institut für Umweltmedizin UNIKA‑T, Technische Universität München und Helmholtz Zentrum München, Neusäßer Str. 47, 86156, Augsburg, Deutschland. c.traidl-hoffmann@tum.de.

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|May 22, 2019

Summary

This summary is machine-generated.

The skin microbiome, an imbalance of bacteria, viruses, and fungi, is linked to atopic eczema. Altered skin microbiomes in atopic eczema patients may impact skin barrier function and inflammation.

Keywords:

Allergies Dysbiosis Immune system Inflammation Microbiota

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Area of Science:

Dermatology
Microbiology
Immunology

Background:

Atopic eczema is a chronic inflammatory skin disease.
It involves skin barrier disruption, inflammation, and microbial imbalance (dysbiosis).
Atopic eczema is associated with allergies, rhinoconjunctivitis, and asthma.

Purpose of the Study:

To clarify the influence of dysbiosis and the cutaneous microbiome on atopic eczema development and severity.
To investigate the role of the skin microbiome in atopic eczema pathogenesis using modern sequencing methods.

Main Methods:

Discussion of current basic research findings on the skin microbiome and atopic eczema.

Main Results:

The human skin microbiome varies by body region, age, and gender.
It interacts with the skin barrier and immune system.
Atopic eczema patients exhibit dysbiosis, with increased Staphylococcus aureus and reduced commensal bacteria, potentially affecting skin barrier function and inflammation.

Conclusions:

Recent advances have improved understanding of the skin microbiome.
This knowledge enhances comprehension of atopic eczema pathogenesis.
Findings may inform future treatment and prevention strategies for atopic eczema.