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Real-time optical fiber sensors based on light diffusing microlens arrays.

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Researchers developed novel optical fiber sensors using biocompatible hydrogels for real-time medical diagnostics. These sensors offer a promising solution to reduce immune responses in implantable devices and enable practical point-of-care monitoring.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Optoelectronics

Background:

  • Implantable optical fiber sensors face challenges due to biological tissue incompatibility and immune reactions.
  • Biocompatible materials are crucial for reducing immune responses in in vivo photonic sensing platforms.

Purpose of the Study:

  • To develop real-time optical fiber sensors for measuring volumetric changes in stimuli-responsive polymers.
  • To create biocompatible photonic sensing probes for medical diagnostics.

Main Methods:

  • Replicated asymmetric microlens structures on stimuli-sensitive hydrogels.
  • Chemically attached hydrogel microlenses to silica and biocompatible optical fibers.
  • Utilized smartphone-based quantitative measurements for readout.

Main Results:

  • Demonstrated real-time sensing of ethanol, propan-2-ol, and dimethyl sulfoxide concentrations.
  • Achieved a pH sensitivity of 40 nW pH-1 in the acidic region for fiber probes.
  • Developed hydrogel optical fiber probes with a reflection configuration sensitivity of 7 nW pH-1.

Conclusions:

  • The developed hydrogel fiber probes are practical for real-time sensing applications.
  • These probes show potential for point-of-care diagnostics, continuous biomarker monitoring, and critical care sensing.
  • The use of biocompatible materials enhances the suitability of optical fiber sensors for in vivo applications.