Related Experiment Video
Updated: Jan 24, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Formulation development and accelerated stability testing of a novel sunscreen cream for ultraviolet radiation
Nilutpal Sharma Bora1,2, Bhaskar Mazumder2, Pompy Patowary1,2
1a Division of Pharmaceutical Technology, Defence Research Laboratory , Defence Research and Development Organization, Ministry of Defence, Government of India , Tezpur , India.
Abstract:
The present study is aimed at the development of a sunscreen cream for use in high altitude areas which have been found to possess superior sun protection factor (SPF) along with remarkable antioxidant activity. The topical formulation is a standard oil-in-water emulsion of a combination of United States Food and Drug Administration (US FDA) approved ultraviolet filters; along with melatonin and pumpkin seed oil. The in-silico optimized formulation was characterized using established methods and the stability study was carried out as per International Conference on Harmonization guidelines. The formulation was prepared after requisite pre-formulation analysis by Fourier-transform infrared spectroscopy, differential scanning calorimetric and thermogravimetric analyses; followed by characterization based on color, odor, phase separation, spreadability, specific gravity, homogeneicity, centrifugation and sensitivity. For the stability study, a total of three samples from three batches of the finished product were subjected to the stability study. The samples were analyzed for content uniformity, pH, in vitro SPF, rheology, zeta potential, droplet diameter and microbial analysis of the 0th day and also the the end of the storage period. Results obtained from the stability study indicated that the formulation possesses 50+ in vitro SPF value and remained stable for 6 months and 12 months under storage at 40 ± 2 °C and 75 ± 5% relative humidity; and -20 °C ± 5 °C respectively.
More Related Videos
Related Concept Videos
Biological Effects of Radiation
Accelerators
The effectiveness of calcium chloride can...
Nuclear Stability
To hold positively charged protons together...
RNA Stability
Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview
Radiation: Applications
The average...

