Related Experiment Video
Updated: Jan 24, 2026
05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
15.5K
Cortical Visual Impairment in Congenital Cytomegalovirus Infection
Journal of Pediatric Ophthalmology and Strabismus
|May 23, 2019
Summary
Symptomatic congenital cytomegalovirus (CMV) infection can cause cortical visual impairment (CVI). Identifying risk factors like microcephaly and seizures may help predict CVI in infants with congenital CMV.
Area of Science:
- Ophthalmology
- Pediatrics
- Infectious Diseases
Background:
- Congenital cytomegalovirus (CMV) infection is a common cause of sensorineural hearing loss and can lead to neurological deficits.
- Cortical visual impairment (CVI) is a significant cause of visual impairment in children, often associated with brain injury.
Purpose of the Study:
- To investigate the presentation, evolution, and long-term outcomes of CVI in infants with symptomatic congenital CMV.
- To identify specific risk factors associated with the development of CVI in this population.
Main Methods:
- Retrospective subanalysis of a long-term prospective cohort study.
- Data collected from 1982 to 2013.
Main Results:
- 14.3% of symptomatic congenital CMV patients developed CVI, compared to none with asymptomatic infection.
- Worse visual outcomes were observed in symptomatic CMV patients compared to asymptomatic and control groups.
- Risk factors for CVI included microcephaly, intracranial calcification, ventricular dilatation, encephalomalacia, seizures, optic atrophy, chorioretinitis, strabismus, and hearing loss.
Conclusions:
- Symptomatic congenital CMV infection is a potential cause of CVI.
- Predictive modeling using identified risk factors could aid in early CVI detection.
- Early CVI screening in infants with symptomatic congenital CMV is crucial for timely interventions.
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
436
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
436
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
265
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
265
01:20Infection
12.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
12.0K
01:26Stages of Infection
65.1K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.1K
01:26Visual System
1.7K
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
1.7K
01:26Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K