Related Experiment Video
Updated: Jan 24, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
Cu(II)-Mediated Ortho-C-H Amination of Arenes with Free Amines
Manoj Kumar1, Shalini Verma1, Pawan K Mishra1
1Synthetic Organic Chemistry Research Laboratory, Department of Chemistry , University of Delhi , Delhi 110007 , India.
Abstract:
Copper-mediated direct ortho-C-H amination of arenes has been accomplished with the aid of easily removable bidentate pyridine N-oxide as a directing group. The use of free cyclic secondary amines and anilines as aminating agents and inexpensive copper acetate makes the strategy more effective and favorable from the economic point of view. This reaction is compatible with a wide range of functional groups to synthesize a variety of amine-containing products of high interest. This method also allows the short synthesis of the central scaffold of pharmaceutically relevant Staphylococcus aureus Sortase A inhibitors.
Related Concept Videos
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Preparation of Amines: Alkylation of Ammonia and Amines
Each alkylation step makes the nitrogen center more nucleophilic, which triggers successive alkylations until a quaternary ammonium salt is formed. Considering...
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Structure of Amines
Amines: Introduction
NMR Spectroscopy Of Amines

