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Tushar R Choudhary1,2,3, Michael G Tanner2,4, Alicia Megia-Fernandez5

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This study presents a novel flexible optical fiber sensor for precise in vivo physiological measurements. The sensor enables accurate, real-time monitoring of pH and oxygen levels deep within tissue, addressing a key clinical challenge.

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Area of Science:

  • Biomedical Engineering
  • Optical Sensing
  • In Vivo Diagnostics

Background:

  • Physiological sensing deep within biological tissues presents significant clinical challenges.
  • Minimally invasive techniques are crucial for accurate in vivo measurements.

Purpose of the Study:

  • To develop a flexible, miniaturized sensing optrode for minimally invasive in vivo, in situ physiological measurements.
  • To enable high-precision photonic measurements of pH and oxygen concentration in challenging anatomical locations.

Main Methods:

  • Fabrication of a sensing optrode by depositing silica microspheres functionalized with ratiometric fluorophores onto etched pits of a 150 µm optical fiber.
  • Utilizing carboxyfluorescein-coupled silica microspheres to detect pH via inverse fluorescence shift.
  • Implementing photonic measurements for oxygen concentration determination.

Main Results:

  • Demonstrated high-density deposition of functionalized silica microspheres on an optical fiber.
  • Achieved precise measurements of pH (±0.02 units) and oxygen concentration (±0.6 mg/L) in the distal alveolar space.
  • Observed near-instantaneous response times for both pH and oxygen sensing.

Conclusions:

  • The developed flexible sensing optrode offers a viable platform for minimally invasive physiological monitoring.
  • The technology provides fast, accurate, and real-time data for pH and oxygen levels.
  • The flexible architecture allows for the integration of multiple sensors for comprehensive physiological assessment.