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Related Experiment Video

Updated: Jan 24, 2026

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

Telomeres in neurological disorders.

Ayyappan Anitha¹, Ismail Thanseem¹, Mahesh Mundalil Vasu¹

¹Institute for Communicative and Cognitive Neurosciences (ICCONS), Palakkad, Kerala, India.

Advances in Clinical Chemistry

|May 25, 2019

Summary

Telomere shortening is linked to aging and neurological diseases like Alzheimer's and depression. Further research is needed to understand the cause-effect relationship and explore telomerase activation as a potential therapy.

Keywords:

Alzheimer Autism Depression Parkinson Schizophrenia Telomerase Telomere

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Published on: January 17, 2019

Area of Science:

Genetics
Neuroscience
Cell Biology

Background:

Telomeres protect chromosome ends and shorten with age, impacting cellular aging.
Telomere attrition rate increases with certain pathological conditions.
Telomere shortening is implicated in the pathogenesis of neurological disorders such as Alzheimer's disease and depression.

Purpose of the Study:

To review the association between telomere shortening and neurological disorders.
To explore the role of telomere maintenance in brain stem cells.
To discuss potential therapeutic strategies involving telomerase activation.

Main Methods:

Literature review of studies on telomere attrition in neurological disorders.
Analysis of the relationship between telomere length and disease status.
Examination of factors contributing to telomere erosion.

Main Results:

An association between telomere shortening and disease status is demonstrated in schizophrenia, Alzheimer's disease, and depression.
Studies on autism spectrum disorders and Parkinson's disease have yielded inconclusive results.
The cause-effect relationship between telomere length and neurological disorders remains unclear.

Conclusions:

Telomere attrition is associated with several neurological disorders, but the causal link is not fully established.
Further research is needed to elucidate the factors responsible for telomere erosion in neurological diseases.
Telomerase activation presents a potential therapeutic avenue for neurological disorders.