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Published on: January 19, 2019
Multifunctional DNA Origami Nanoplatforms for Drug Delivery
Xuehe Lu1,2, Jianbing Liu2, Xiaohui Wu2,3
1School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China.
Abstract:
DNA nanotechnology has been employed in the construction of self-assembled nano-biomaterials with uniform size and shape for various biological applications, such as bioimaging, diagnosis, or therapeutics. Herein, recent successful efforts to utilize multifunctional DNA origami nanoplatforms as drug-delivery vehicles are reviewed. Diagnostic and therapeutic strategies based on gold nanorods, chemotherapeutic drugs, cytosine-phosphate-guanine, functional proteins, gene drugs, and their combinations for optoacoustic imaging, photothermal therapy, chemotherapy, immunological therapy, gene therapy, and coagulation-based therapy are summarized. The challenges and opportunities for DNA-based nanocarriers for biological applications are also discussed.
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