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Related Experiment Videos

Left ventricular function in adults with atrial septal defect.

P I Altieri, J Martínez Toro, L Del Valle

    Puerto Rico Health Sciences Journal
    |April 1, 1987
    PubMed
    Summary

    Secundum atrial defect can cause subnormal left ventricular ejection fraction and abnormal wall motion. Nitroglycerin improved ejection fraction, suggesting these abnormalities may be primary, not shunt-related.

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    Area of Science:

    • Cardiology
    • Cardiovascular Physiology

    Background:

    • Secundum atrial defect (SAD) is a common congenital heart condition.
    • Left ventricular (LV) function in SAD patients requires further investigation.

    Purpose of the Study:

    • To analyze left ventricular systolic function and wall motion in patients with secundum atrial defect.
    • To investigate the effect of nitroglycerin on LV function in SAD patients.

    Main Methods:

    • Cardiac catheterization was performed on 16 SAD patients.
    • Analysis focused on end-systolic and mid-ejection LV parameters.
    • Eight patients underwent restudy after sublingual nitroglycerin administration.

    Main Results:

    • Mean ejection fraction was subnormal (57 ± 8%) compared to controls (71 ± 10%).

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  • Elevated end-diastolic volumes were observed in 8 patients.
  • Nitroglycerin improved ejection fraction from 54% to 70% and normalized hypokinetic areas.

    • Conclusions:

    • Patients with secundum atrial defect exhibit impaired left ventricular systolic function.
    • LV wall motion abnormalities in SAD may be primary, independent of shunt size.
    • Nitroglycerin demonstrates potential therapeutic benefit in improving LV function in SAD.