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[Morphological changes in broilers produced by feeding antibiotics].

A Veselinova, N Ivanov, D Chotinski

    Veterinarno-Meditsinski Nauki
    |January 1, 1987
    PubMed
    Summary

    Antibiotic feed additives like flavomycin caused significant liver and kidney damage in broiler birds. Morphological changes in organs depended on the antibiotic dosage, with flavomycin showing the most pronounced effects.

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    Area of Science:

    • Veterinary Pathology
    • Animal Science
    • Toxicology

    Background:

    • Antibiotics are widely used in poultry farming to promote growth and prevent disease.
    • Understanding the potential adverse effects of these feed additives on animal health is crucial.
    • Morphological changes in vital organs can indicate toxicity and impact animal welfare.

    Purpose of the Study:

    • To investigate the morphologic effects of specific feed antibiotics on broiler chickens.
    • To compare the impact of different antibiotics (virginiamycin, flavomycin, avotan) on liver, kidney, and small intestine tissues.
    • To determine if the observed changes correlate with the dosage of antibiotics administered.

    Main Methods:

    • Histopathological examination of liver, kidney, and small intestine tissues from broiler birds.
    • Broiler chickens were administered feed containing virginiamycin, flavomycin, or avotan for 49 days.
    • Comparison of tissue morphology between antibiotic-treated groups and a control group.

    Main Results:

    • Antibiotic administration resulted in protein and fatty dystrophy in the liver and protein dystrophy in the kidneys.
    • The small intestine showed wall thinning and increased villi length in treated birds.
    • Flavomycin induced more severe lesions compared to virginiamycin and avotan, indicating a dose-dependent effect.

    Conclusions:

    • Feed antibiotics can induce significant morphologic changes in broiler chickens' vital organs.
    • The severity of these changes is influenced by the type and dosage of the antibiotic.
    • These findings highlight potential health risks associated with antibiotic use in poultry production.

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