Related Experiment Video
Updated: Jan 24, 2026
07:45
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
Published on: December 30, 2025
325
Update on Screening for Sight-Threatening Diabetic Retinopathy.
Peter H Scanlon1,2,3,4
1Clinical Director English NHS Diabetic Eye Screening Programme, Cheltenham, United Kingdom, p.scanlon@nhs.net.
Ophthalmic Research
|May 28, 2019
Summary
Recent advances in diabetic retinopathy screening technology show promise for improving sight-saving programs. Further studies must confirm the effectiveness and cost-effectiveness of these new diagnostic tools before widespread adoption.
Area of Science:
- Ophthalmology
- Medical Technology
- Public Health
Background:
- Diabetic retinopathy is a leading cause of preventable blindness.
- Early detection through screening is crucial for timely intervention.
- Technological advancements offer potential improvements in screening efficiency and accuracy.
Purpose of the Study:
- To review recent technological advancements in diabetic retinopathy screening.
- To evaluate the effectiveness and cost-effectiveness of these new technologies.
Main Methods:
- Systematic literature search using Zetoc database.
- Inclusion of articles on screening and management of diabetic retinopathy.
- Analysis of studies assessing technological effectiveness and cost-effectiveness.
Main Results:
- Exploration of various technologies including digital photography alternatives, camera size, and field of view.
- Discussion on mydriasis protocols, visual acuity measurement, and image grading.
- Assessment of automated grading analysis and overall cost-effectiveness.
Conclusions:
- Numerous technological innovations exist for diabetic retinopathy screening.
- Each new technology requires rigorous validation of its effectiveness and cost-effectiveness.
- Widespread adoption hinges on demonstrated clinical and economic benefits.
Related Concept Videos
01:29Sight Distance in a Vertical Curve
353
Sight distance on vertical curves is critical in roadway design. It ensures drivers can see far enough ahead to identify and respond to hazards effectively. This directly impacts safety, driver comfort, and the overall efficiency of the transportation network.Vertical curves are classified into crest and sag curves based on their geometry. For crest curves, sight distance is determined by the line of sight between a driver's eye and a small object on the road's surface. Design parameters for...
353
01:20Pathophysiology of Diabetes
3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.3K
01:15Diabetes: Management and Pharmacotherapy
885
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
885
01:19Psychoneuroimmunology: Diabetes and Cancer
470
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
470
01:22Diabetes Mellitus: Type 2 and Gestational
4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.1K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K