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Updated: Jan 24, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
Published on: February 9, 2012
A fluorogenic BODIPY molecular rotor as an apoptosis marker
Pichandi Ashokkumar1, Anila Hoskere Ashoka, Mayeul Collot
1Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, Strasbourg CS 60024, France. andrey.klymchenko@unistra.fr mayeul.collot@unistra.fr.
Abstract:
Based on a BODIPY molecular rotor and a zinc-dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.
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