Left ventricular dyssynchrony assessment using tissue synchronization imaging in acute myocardial infarction
Ahmed S Azazy1, Mahmoud Soliman2, Rehab Yaseen2
1Department of Cardiology, King Saud Medical City, Riyadh, Saudi Arabia.
Avicenna Journal of Medicine
|May 31, 2019
Summary
Patients with ST elevation myocardial infarction (STEMI) exhibit significant left ventricular (LV) dyssynchrony. This dyssynchrony is linked to reduced LV ejection fraction and predicts in-hospital complications.
Area of Science:
- Cardiology
- Cardiac Imaging
- Myocardial Infarction Research
Background:
- Mechanical dyssynchrony in the left ventricle (LV) impairs cardiac function.
- This leads to reduced LV ejection fraction (LVEF) and stroke volume.
- It also causes abnormal wall tension and increased cardiac workload.
Purpose of the Study:
- To evaluate left ventricular (LV) dyssynchrony in patients diagnosed with ST elevation myocardial infarction (STEMI).
- To investigate the relationship between LV dyssynchrony and clinical outcomes in STEMI patients.
Main Methods:
- Enrolled 56 participants: 36 with acute STEMI and 20 healthy controls.
- Measured time to peak myocardial velocity using 2D-tissue strain imaging.
- Analyzed 12 LV segments for dyssynchrony using automated color-coded velocity mapping.
Main Results:
- STEMI patients showed significant delays between septal-lateral and septal-posterior walls compared to controls.
- Higher dyssynchrony index (all segment SD) observed in STEMI group (44.47ms vs. 26.45ms).
- LV dyssynchrony parameters negatively correlated with LVEF and positively with LV end-systolic dimension.
Conclusions:
- Acute STEMI patients demonstrate significant left ventricular (LV) dyssynchrony.
- LV dyssynchrony is an independent predictor of in-hospital complications in STEMI patients.
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