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Nanovesicles for Nanomedicine: Theory and Practices
Sheetu Wadhwa1, Varun Garg1, Monica Gulati1
1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Methods in Molecular Biology (Clifton, N.J.)
|June 1, 2019
Summary
Novel nanovesicles like liposomes offer unique drug delivery capabilities for both lipophilic and hydrophilic compounds. Despite challenges in reaching disease sites, these nanocarriers show significant promise for advanced therapeutics and diagnostics.
Area of Science:
- Nanotechnology and Pharmaceutical Sciences
- Biomedical Engineering
- Drug Delivery Systems
Background:
- Lipid-based nanovesicles, including liposomes, niosomes, and ethosomes, are established as promising platforms for drug delivery and theranostics.
- These nanocarriers possess the unique ability to encapsulate both lipophilic drugs within their lipid bilayers and hydrophilic drugs in their aqueous core.
- The transition of some nanovesicles from research to market highlights their therapeutic potential.
Purpose of the Study:
- To provide an in-depth overview of the role of novel nanovesicles in advancing drug delivery applications.
- To discuss the formulation, characterization, and diverse applications of various nanovesicles.
- To highlight current and potential challenges in utilizing nanovesicles for effective drug targeting and delivery.
Main Methods:
- Review and synthesis of existing literature on lipid-based nanovesicles.
- Overview of formulation strategies and characterization techniques for nanovesicles.
- Analysis of nanovesicle applications in drug delivery and theranostics.
Main Results:
- Nanovesicles demonstrate versatility in drug encapsulation, accommodating both lipophilic and hydrophilic agents.
- Significant progress has been made, with some nanovesicle formulations already available commercially.
- Physiological and pathological conditions present key challenges to effective drug delivery at disease loci.
Conclusions:
- Novel nanovesicles represent a significant advancement in drug delivery technology, offering targeted and efficient therapeutic solutions.
- Continued research into formulation and overcoming delivery challenges is crucial for maximizing the potential of these nanocarriers.
- Nanovesicles hold considerable promise for future theranostic applications and personalized medicine.
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