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Phospholipid Micelles for Peptide Drug Delivery
Karina Esparza1, Dulari Jayawardena1, Hayat Onyuksel2
1Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Methods in Molecular Biology (Clifton, N.J.)
|June 1, 2019
Summary
Sterically stabilized micelles (SSM) offer a novel nanocarrier for peptide drug delivery. This method simplifies the formulation of unstable peptides, facilitating their clinical development and market transition.
Area of Science:
- Nanotechnology
- Drug Delivery
- Biomedical Engineering
Background:
- Sterically stabilized micelles (SSM) are self-assembled nanoparticles.
- DSPE-PEG2000, a biocompatible and biodegradable component, forms the SSM.
- SSM are ideal for delivering therapeutic peptides, overcoming formulation challenges.
Purpose of the Study:
- To describe methods for preparing and characterizing peptide-associated SSM (peptide-SSM).
- To discuss approaches for evaluating the biological activity of peptide nanomedicines.
- To highlight the potential of SSM for clinical peptide drug development.
Main Methods:
- Preparation of sterically stabilized micelles (SSM).
- Characterization of peptide-SSM formulations.
- In vitro and in vivo evaluation of peptide nanomedicine activity.
Main Results:
- SSM formulation enables the delivery of therapeutic peptides.
- Simple and scalable preparation of peptide-SSM.
- Methods for comprehensive characterization and biological evaluation are presented.
Conclusions:
- SSM represent a promising nanocarrier for peptide-based therapeutics.
- The ease of preparation and scalability facilitate clinical translation.
- This approach addresses instability issues, enabling peptide drug development.
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