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Updated: Jan 24, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Mohs micrographic surgery for melanoma: A prospective multicenter study.
Patrick M Ellison1, John A Zitelli2, David G Brodland2
1John Boyer, MD, Inc, The Queens Medical Center, Honolulu, Hawaii.
Mohs micrographic surgery (MMS) effectively treats cutaneous melanoma, achieving negative margins with specific excision widths for different body areas. This single-day procedure offers tissue conservation and same-day reconstruction.
Area of Science:
- Dermatology
- Surgical Oncology
Background:
- Single-institution studies suggest Mohs micrographic surgery (MMS) is effective for cutaneous melanoma.
- No multi-institutional studies have previously evaluated MMS for melanoma treatment.
Purpose of the Study:
- To characterize MMS use for melanoma across US academic and private practices.
- To recommend excision margins for cases without 100% margin evaluation.
- To compare MMS costs with standard surgical excision.
Main Methods:
- Prospective, multicenter cohort study.
- Involved 562 melanomas treated with MMS and MART-1 immunostaining.
Main Results:
- 10-mm margins achieved 97% negative margins for trunk/extremity melanomas.
- 12-mm margins were needed for 97% negative margins in head and neck melanomas.
- Average cost per tumor was $1328.46.
Conclusions:
- MMS with MART-1 immunostaining enables tissue conservation and same-day reconstruction.
- Recommends 10mm margins for trunk/extremity and 12mm for head/neck melanomas when comprehensive evaluation is absent.
- Study limitations include nonrandomized and noncontrolled design.
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