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Updated: Jan 24, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols
Nikita E Golantsov1, Hung M Nguyen1, Alexandra S Golubenkova1
1Department of Organic Chemistry, Faculty of Science, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Abstract:
A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides.
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