[The correlations between serum vitamin D, parathyroid hormone, and bone mineral density with benign paroxysmal...

Objective:To detect serum 25-hydroxyvitamin D[25-（OH）₂-VitD₃], parathyroid hormone (PTH), and bone mineral density in patients with benign paroxysmal positional vertigo (BPPV), and to analyze their correlations with BPPV. Method:Fifty cases of BPPV were selected as the study group, 50 healthy persons were selected as control group. Chemiluminescence assay was used to detect serum VD level, chemiluminescence immunoassay was used to detect serum PTH level, dual energy X-ray absorptiometry was used to detect bone mineral density (BMD) and T value of lumbar vertebrae 1 to lumbar vertebrae 4 in two groups. Result:The serum 25-（OH）₂-VitD₃ level in the study group was significantly lower than that in the control group (P<0.05); the serum PTH level of the study group was significantly higher than that of the control group (P<0.05); there was no significant difference in T value between male BPPV patients and female BPPV patients younger than 48 years old with the control group (P>0.05), T value of female BPPV patients older than 48 years old was significantly lower than that of the control group (P<0.05). Logistic regression analysis showed that the decrease of serum 25-（OH）₂-VitD₃ level, the increase of PTH level, and the decrease of bone mineral density were risk factors for BPPV. Conclusion:The level of serum 25-（OH）₂-VitD₃ is decreased in BPPV patients, PTH level is increased and bone mineral density is decreased, they are risk factors for BPPV.