Related Experiment Video
Updated: Jan 23, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Comparative Analysis of Blood Plasma Proteome in Patients with Renal Cell Carcinoma
A L Kaysheva1, A T Kopylov2, N E Kushlinskii3
1V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. kaysheva1@gmail.com.
Abstract:
Comparative mass spectrometric analysis of protein composition was carried out in 36 blood plasma specimens from patients with renal cell carcinoma and 20 specimens from donors. Analysis of protein composition of plasma specimens devoid of the major protein fractions showed a 20-50% higher level of protein identifications in patient' specimens. Specimens of the control and experimental series were similar by protein composition, 70-80% identifications in experimental and control series coinciding. High similarity of biological processes with participation of the proteins identified in both series was observed. The greater part of proteins in both series were located extracellularly and were exosomal (specimens from renal cancer patients) or vesicular (specimens from healthy volunteers).
More Related Videos
Related Concept Videos
Protein Buffers in Blood Plasma and Cells
Certain amino acids can exist in a zwitterion state at a...
Composition of Blood Plasma
Comparing the Survival Analysis of Two or More Groups
Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

