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Highlighted STAT3 as a potential drug target for cancer therapy

Haeri Lee1, Ae Jin Jeong1, Sang-Kyu Ye2

  • 1Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

BMB Reports
|June 13, 2019
PubMed

Insights

Signal transducer and activator of transcription 3 (STAT3) is crucial in cancer development and the tumor microenvironment. Targeting STAT3 signaling may inhibit tumor progression and enhance anti-cancer immunity.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Immunology

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor regulating critical cellular processes.
  • Aberrant STAT3 activation promotes tumor progression and malignancy in various cancers.
  • STAT3 in immune cells contributes to an immunosuppressive tumor microenvironment.

Purpose of the Study:

  • To review the multifaceted role of STAT3 in cancer.
  • To explore the intricate relationship between STAT3 and the tumor microenvironment.
  • To present inhibitors targeting STAT3 signaling pathways.

Main Methods:

  • Literature review of STAT3's function in oncogenesis.
  • Analysis of STAT3's interaction with the tumor microenvironment.
  • Compilation of STAT3 signaling inhibitors.

Main Results:

  • STAT3 dysregulation drives oncogenic gene expression and tumor malignancy.
  • STAT3 activation in immune cells elevates immunosuppressive factors.
  • The tumor microenvironment significantly influences STAT3 signaling.

Conclusions:

  • Targeting STAT3 offers a promising strategy to impede tumor progression.
  • Inhibiting STAT3 may enhance anti-cancer immune responses.
  • STAT3 inhibitors represent potential therapeutic agents for cancer treatment.

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