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Liquid biopsy for lung cancer immunotherapy
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
Oncology Letters
|June 13, 2019
Summary
Immune checkpoint inhibitors (CPIs) show promise in lung cancer, but resistance limits effectiveness. Liquid biopsy may identify patients benefiting from immunotherapy and guide precision medicine strategies.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Immune checkpoint inhibitors (CPIs) like anti-programmed death receptor-1 (PD-1) are crucial for cancer immunotherapy, especially in tumors with high mutation burden.
- Adoptive cell therapies, including T-cell receptor-engineered T cells targeting neoantigens (neo-Ags), offer novel treatment options for lung cancer.
Purpose of the Study:
- To review current literature and clinical trials on lung cancer management using immunotherapy for precision medicine.
- To discuss the role of potential biomarkers in liquid biopsies for predicting immunotherapy response and guiding treatment decisions.
Main Methods:
- Comprehensive literature review of recent studies and clinical trials on lung cancer immunotherapy.
- Analysis of resistance mechanisms to CPIs and their association with systemic anticancer therapy.
- Evaluation of liquid biopsy as a tool for biomarker discovery in lung cancer immunotherapy.
Main Results:
- CPIs demonstrate therapeutic efficacy, particularly in tumors with high tumor mutation burden.
- Resistance to immunotherapy remains a challenge, with unclear associations with other systemic therapies.
- Liquid biopsy holds potential for identifying biomarkers to predict patient response to immunotherapy.
Conclusions:
- Personalized immunotherapy strategies are essential for effective lung cancer treatment.
- Further research into resistance mechanisms and biomarker discovery via liquid biopsy is critical for advancing precision medicine in lung cancer.
Keywords:
T cellscheckpoint inhibitorsliquid biopsylung cancerneoantigensprognosistumor mutation burdenMore Related Videos
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