VarMap: a web tool for mapping genomic coordinates to protein sequence and structure and retrieving protein...

Area of Science:

• Genomics
• Structural Biology
• Bioinformatics

Background:

• Understanding genomic variants' impact on protein structure is crucial for distinguishing benign from pathogenic mutations.
• Mapping genomic coordinates to protein structures is complex due to alternative splicing and transcript variations.

Purpose of the Study:

• To present VarMap, a novel web tool designed to map genomic variants to protein structures.
• To facilitate the interpretation of genomic variants by providing structural context.

Main Methods:

• VarMap accepts lists of chromosome coordinates.
• It maps these coordinates to canonical UniProt sequences and corresponding 3D protein structures.
• The tool includes validation checks and annotates variants with structural information.

Main Results:

• VarMap provides a streamlined approach for mapping genomic variants to protein structures.
• The tool facilitates the annotation of variants with relevant structural data.
• It aids in the interpretation of variant pathogenicity by providing structural context.

Conclusions:

• VarMap is a valuable resource for researchers studying genomic variants and their structural consequences.
• The tool simplifies the process of linking genomic information to protein 3D structures.
• VarMap enhances the understanding of molecular mechanisms underlying genetic variations.