Eustachian tube dysfunction in children with cleft palate: A tympanometric time-to-event analysis
Jamie L Funamura1, Mena Said1, Sharon J Lin1
1Department of Otolaryngology-Head & Neck Surgery, UC Davis Health, Sacramento, California, U.S.A.
Insights
Children with cleft palate experience delayed Eustachian tube function, with normal tympanograms achieved significantly later than in children with cleft lip only. This delay is not linked to cleft severity.
Area of Science:
- Otolaryngology
- Pediatric Health
- Genetics and Developmental Biology
Background:
- Eustachian tube dysfunction (ETD) is common in children with cleft palate.
- Understanding the duration and predictors of ETD is crucial for managing otologic complications.
Purpose of the Study:
- To compare the time to resolution of ETD in children with cleft palate versus those with cleft lip only.
- To identify factors predicting earlier resolution of ETD in children with cleft palate.
Main Methods:
- Longitudinal tympanometric data from over 10 years were analyzed.
- Time-to-event analysis (Cox proportional hazard models) was used to compare groups.
- Association between tympanometry results and clinical/demographic factors was assessed.
Main Results:
- Children with cleft palate achieved normal tympanograms (Type A) at a median age of 9.9 years (one ear) and 12.1 years (both ears).
- This is significantly later than children with cleft lip only (7.1 and 7.4 years, respectively).
- Cleft severity or associated syndromes did not predict the time to normal tympanograms.
Conclusions:
- Children with cleft palate exhibit a delayed onset of normal Eustachian tube function.
- The degree of palatal clefting does not influence the duration of Eustachian tube dysfunction.
Objectives:
To characterize the duration of Eustachian tube dysfunction in children with cleft palate compared to those without cleft palate by performing time-to-event analysis on tympanometric data. To determine predictive characteristics of earlier achievement of normal tympanograms in children with cleft palate.
Methods:
Longitudinal tympanometric data from a minimum of 10 years at a single center were reviewed for children with cleft palate born in the years 2003 through 2007. Children with cleft lip without cleft palate born in the same years were used as a reference group to compare children with similar length of follow-up. The association between time to sustained normal (type A) tympanograms with patient demographics, clinical characteristics, and otologic history was evaluated using time-to-event analysis and compared with log rank tests. Adjusted and unadjusted hazard ratios were estimated using Cox proportional hazard models.
Results:
The median age of achieving a type A tympanogram in children with cleft palate was 9.9 years for one and 12.1 years for both ears, compared to 7.1 and 7.4 years in children with cleft lip only (P < 0.0001). On multivariate analysis, clinical characteristics such as the severity of palatal clefting or the presence of a cleft-associated syndrome/sequence were not predictors of a longer time to a type A tympanogram.
Conclusion:
Our results help characterize the observation that there is delayed time to normal Eustachian tube function in children with cleft palate, which is not associated with the degree of palatal clefting.
Level Of Evidence:
3b Laryngoscope, 130:1044-1050, 2020.
Related Concept Videos
Noncompartmental Analysis: Mean Residence Time
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
Uterine Tubes
Integration of Synaptic Events
Endotracheal Tube Extubation
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
Tracheostomy: Procedure and Tubes
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...


