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Updated: Jan 23, 2026

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
Published on: June 24, 2013
Structurally related glucosylated liposomes: Correlation of physicochemical and biological features
Alessandro Mauceri1, Luisa Giansanti2, Giuseppina Bozzuto3
1Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, (Italy).
Abstract:
Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated. Our results show that the hydrophobic portion of the lipid bilayer strongly influences both the properties and the internalization of glycosylated liposomes.
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