Spatial distribution characteristics of tumor marker CA724 reference values in China

Area of Science:

• Environmental Health
• Biomarker Research
• Geographical Epidemiology

Background:

• Cancer antigen 724 (CA724) is a tumor marker with established clinical relevance.
• Understanding the geographical distribution of CA724 reference values is crucial for accurate diagnosis.
• Spatial variations in CA724 may be influenced by environmental and demographic factors.

Purpose of the Study:

• To investigate the spatial distribution characteristics of CA724 reference values in healthy Chinese adults.
• To identify geographical environmental factors associated with CA724 reference value variations.
• To develop a predictive model for CA724 reference values based on environmental data.

Main Methods:

• Analysis of CA724 reference values from 34,470 healthy adults across 106 cities over 10 years.
• Correlation analysis and RBF artificial neural networks to assess relationships between CA724 and 25 environmental factors.
• Geostatistical mapping using Kriging interpolation to reveal spatial distribution patterns.

Main Results:

• CA724 reference values exhibit a significant downward trend from south to north in China.
• Negative correlations were observed with latitude, sunshine duration, and soil cation exchange capacity.
• Positive correlations were found with annual mean air temperature, relative humidity, and precipitation.

Conclusions:

• CA724 reference values demonstrate spatial autocorrelation and regional variations influenced by geographical factors.
• Environmental factors like temperature, humidity, and sunshine impact CA724 levels, potentially affecting gastrointestinal health.
• These findings offer novel insights for future prevention strategies and clinical diagnosis of CA724-related conditions.