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Cerebral microbleeds are not associated with postoperative delirium and postoperative cognitive dysfunction in older

Gunnar Lachmann1,2, Ilse Kant3, Florian Lammers1

  • 1Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité-Unversitätsmedizin Berlin, Berlin, Germany.

Plos One
|June 15, 2019
PubMed
Abstract

Insights

This study found no link between preoperative cerebral microbleeds (CMB) and postoperative delirium (POD) or cognitive dysfunction (POCD) in older surgical patients. Further research is needed to understand CMB

Area of Science:

  • Neurology
  • Geriatrics
  • Radiology

Background:

  • Cerebral microbleeds (CMB) are markers of cerebral small vessel disease.
  • Other small vessel disease markers are linked to postoperative cognitive issues, but CMB's role is unclear.
  • This study investigates CMB's association with postoperative delirium (POD) and cognitive dysfunction (POCD).

Purpose of the Study:

  • To determine if preoperative cerebral microbleeds (CMB) are associated with postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in older adults undergoing surgery.

Main Methods:

  • 65 older patients undergoing elective surgery were included.
  • Preoperative cerebral MRI with 3D susceptibility-weighted imaging detected CMB.
  • POD and POCD were assessed using standardized criteria and cognitive tests up to 3 months post-surgery.

Main Results:

  • 17 patients (26%) had preoperative CMB.
  • POD occurred in 22% of patients, and POCD occurred in 20% at 7 days and 8% at 3 months.
  • No significant association was found between CMB and the occurrence of POD or POCD at any time point.

Conclusions:

  • Preoperative cerebral microbleeds (CMB) were not associated with the development of postoperative delirium (POD) or postoperative cognitive dysfunction (POCD).
  • The role of CMB in postoperative neurological complications requires further investigation.

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