A Real-World, Non-interventional Indian Study Evaluating Intensive Plant-Based Butter Moisturizing Cream in Psoriasis

Area of Science:

• Dermatology
• Real-world evidence
• Patient-reported outcomes

Background:

• Psoriasis affects 0.44-2.8% of the Indian population.
• Moisturizers are crucial for psoriasis management, but Indian-specific data on their efficacy, safety, and compliance is limited.
• A real-world study evaluated an intensive plant-based butter moisturizing cream (Venusia® Max) in Indian psoriasis patients.

Purpose of the Study:

• To assess the effectiveness, safety, and compliance of an intensive plant-based butter moisturizing cream in Indian psoriasis patients.
• To evaluate the cream's impact on quality of life and skin dryness.
• To gather real-world data on adjuvant psoriasis treatment in India.

Main Methods:

• An observational, patient-reported outcomes (PRO) study involving 400 Indian psoriasis patients (aged 18-75 years).
• Patients used the moisturizing cream for 4 weeks in routine clinical practice.
• Primary outcome: Improvement in quality of life (Dermatology Quality of Life Index - DLQI). Secondary outcomes: Improvement in skin dryness (Dry Skin/Ichthyosis Area and Severity Index - DASI), safety, and compliance.

Main Results:

• Significant reductions in mean DLQI score (66.7%, p<0.001) and mean DASI score (84.6%, p<0.001) at 4 weeks compared to baseline.
• The cream exhibited a good safety and compliance profile.
• No serious adverse events or deaths were reported during the study.

Conclusions:

• Real-world use of the intensive plant-based butter moisturizing cream significantly improved quality of life and reduced skin dryness in psoriasis patients over 4 weeks.
• The moisturizing cream is a potentially valuable adjuvant treatment for managing psoriasis.
• The study provides crucial real-world data on moisturizer use in an Indian psoriasis population.