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Therapeutic plasma exchange in hypertriglyceridemic patients

Ilgın Yıldırım Şimşir, Utku Erdem Soyaltın, Banu Sarer Yürekli

    Turkish Journal of Medical Sciences
    |June 18, 2019
    PubMed

    Insights

    Therapeutic plasma exchange (TPE) effectively reduces high triglyceride levels in hypertriglyceridemic pancreatitis (HTGP) patients. This rapid treatment significantly lowers triglyceride concentrations, improving patient outcomes.

    Area of Science:

    • Cardiology
    • Metabolic Disorders
    • Gastroenterology

    Background:

    • High triglyceride (TG) levels are linked to cardiovascular disease, fatty liver disease, and pancreatitis.
    • Acute pancreatitis carries a high mortality rate.
    • Therapeutic plasma exchange (TPE) offers a rapid and effective treatment for hypertriglyceridemic pancreatitis (HTGP).

    Purpose of the Study:

    • To evaluate the effectiveness of TPE in treating HTGP.
    • To determine the frequency of lipoprotein lipase (LPL) mutations in patients with HTGP.

    Main Methods:

    • TPE was administered to 31 patients diagnosed with HTGP.
    • Lipoprotein lipase (LPL) mutation screening was conducted on the patient cohort.

    Main Results:

    • TPE treatment resulted in a median of 2 sessions, achieving TG levels below 500 mg/dL.
    • A significant reduction in mean TG levels was observed, from 3132 ± 1472 mg/dL before TPE to 948 ± 465 mg/dL after TPE (a 69.7% decrease).
    • Lipoprotein lipase (LPL) mutations were identified in 8 out of 31 (25.8%) patients.

    Conclusions:

    • TPE is a safe, rapid, and effective treatment for hypertriglyceridemic pancreatitis (HTGP).
    • The procedure is best performed in experienced therapeutic apheresis centers.
    Abstract

    Keywords:
    Hypertriglyceridemiapancreatitisapheresistherapeutic plasma exchangefresh frozen plasma

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