Recent advances of boronate affinity materials in sample preparation

Area of Science:

• Analytical Chemistry
• Materials Science
• Biochemistry

Background:

• Boronate affinity materials are crucial for isolating cis-diol-containing molecules.
• These molecules, including saccharides and glycoproteins, are vital in environmental, food, and bioanalysis.
• Selective enrichment is essential due to low target abundance and high interference.

Purpose of the Study:

• To review recent developments in boronate affinity materials.
• To discuss their applications in sample preparation over the last three years.
• To analyze how material structure impacts performance and overcomes analytical challenges.

Main Methods:

• Literature review of boronate affinity materials and their applications.
• Focus on material properties, substrate structure effects, and performance metrics (capacity, affinity, selectivity, pH).
• Examination of applications in overcoming sample preparation challenges.

Main Results:

• Boronate affinity materials have seen rapid development and utilization.
• Substrate structure significantly influences binding capacity, affinity, selectivity, and working pH.
• These materials offer significant advantages for sample preparation in complex matrices.

Conclusions:

• Boronate affinity materials are highly effective for enriching cis-diol analytes.
• Understanding material-structure-performance relationships is key to optimizing applications.
• Recent advancements provide powerful tools for challenging sample preparation tasks in various fields.