Thrombus growth modelling and stenosis prediction in the cerebral microvasculature

Cerebral microvascular occlusions cause restriction of blood supply to the brain, thus potentially severely impacting cognitive abilities. Thus, accurate prediction of thrombus growth in realistic geometries is important. Thrombi growth in an existing 13-generation cerebral microvasculature network is simulated here to study the haemodynamic effects of single and multiple blockages on the occlusion of the network. Compared to a single vessel, in a network, the occlusion probability is found to be different. It is the downstream/smaller arterioles (i.e. the 3rd, 4th, 5th, 6th generation arterioles in this study) that tend to reach occlusion first in a network and thus are the critical vessels. Simulations of simultaneous growth of two independent thrombi in the network (referred to here as the two-block case) show a close coupling between the locations of the various blocks in the network, each influencing the other's growth. The presence of the lead block (LB) slows the growth of the trailing block (TB). In some cases, it stops the TB's growth thereby preventing it from occluding the vessel. Findings in this work thus indicate that, to prevent ischaemia, blocks in the smaller arterioles need to be identified and treated first, and that this is more critical if the number of simultaneous blocks is higher.