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Related Concept Videos

Glial Cells01:04

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Organization of the Nervous System01:13

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The nervous system is one of the most complex systems in our body. It is organized into two main divisions: the central nervous system (CNS) and the peripheral nervous system (PNS).
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Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
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Central Nervous System Lymphoma.

Ugonma N Chukwueke1, Lakshmi Nayak1

  • 1Department of Medical Oncology, Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Hematology/Oncology Clinics of North America
|June 24, 2019
PubMed
Summary
This summary is machine-generated.

Primary central nervous system lymphoma (PCNSL) is a rare non-Hodgkin lymphoma. Its incidence is stable, with increasing cases in elderly patients, and methotrexate remains a key treatment.

Keywords:
Central nervous systemDiffuse large B-cell lymphomaExtranodalMethotrexateNon-Hodgkin lymphoma

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Area of Science:

  • Neuro-oncology
  • Hematology
  • Immunology

Background:

  • Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin lymphoma (NHL).
  • PCNSL incidence is stable, with a notable rise in elderly, immunocompetent individuals.
  • Most PCNSL cases originate from diffuse large B-cell lymphoma.

Purpose of the Study:

  • To summarize the epidemiology and management of primary central nervous system lymphoma (PCNSL).
  • To highlight the role of methotrexate in PCNSL prophylaxis and treatment.
  • To discuss ongoing investigations for PCNSL therapies.

Main Methods:

  • Literature review of PCNSL epidemiology.
  • Analysis of treatment strategies for PCNSL.
  • Review of current research in PCNSL management.

Main Results:

  • PCNSL is uncommon, with stable incidence post-highly active antiretroviral therapy.
  • Increasing PCNSL incidence observed in elderly, immunocompetent populations.
  • Methotrexate is the standard of care for PCNSL prophylaxis and treatment.

Conclusions:

  • PCNSL management relies heavily on methotrexate.
  • Further therapeutic investigations are underway for PCNSL.
  • Understanding PCNSL trends is crucial for clinical practice.