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Melatonin deficiency at tissue level: a possible aetiological factor in nasal polyposis
E Senturk1, Y S Yildirim2, O Ozturan1
1Department of Otorhinolaryngology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey.
The Journal of Laryngology and Otology
|June 25, 2019
Summary
Nasal polyposis is associated with lower melatonin levels in both tissue and serum. This melatonin deficiency may contribute to the development of nasal polyps.
Area of Science:
- Otorhinolaryngology
- Endocrinology
- Immunology
Background:
- Nasal polyposis is a chronic inflammatory condition of the upper airway.
- The role of melatonin, a key hormone regulating circadian rhythms, in nasal polyposis pathogenesis is not well understood.
Purpose of the Study:
- To investigate the potential involvement of melatonin in the development of nasal polyps.
Main Methods:
- This study compared melatonin levels in 29 patients with nasal polyposis undergoing surgery and 26 control subjects.
- Tissue samples from nasal polyps and control mucosa, along with serum samples, were analyzed for melatonin concentration.
Main Results:
- Significantly lower tissue and serum melatonin levels were observed in patients with nasal polyposis compared to the control group.
- These findings suggest a correlation between reduced melatonin and the presence of nasal polyps.
Conclusions:
- Melatonin levels are decreased in both the serum and tissue of individuals with nasal polyposis.
- This deficiency in melatonin may play a significant role in the pathogenesis of nasal polyposis, suggesting potential therapeutic implications.
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