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Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes

Habib Yaribeygi1, Alijan Yaribeygi2, Thozhukat Sathyapalan3

  • 1Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Diabetes & Metabolic Syndrome
|June 26, 2019
PubMed

Insights

Trehalose, a natural disaccharide, shows potential as a non-pharmacological approach to manage diabetes. It may help stabilize blood glucose levels and improve insulin sensitivity, offering a new avenue for diabetes management.

Area of Science:

  • Metabolic disorders and diabetes research
  • Nutritional science and food chemistry

Background:

  • Diabetes mellitus is a leading cause of human morbidity and mortality.
  • Effective glycemic control strategies are crucial for diabetes management.
  • Non-pharmacological agents are increasingly explored for their therapeutic potential in diabetes.

Purpose of the Study:

  • To investigate the potential anti-hyperglycemic effects of trehalose.
  • To explore trehalose as a non-pharmacological agent for diabetes management.
  • To evaluate trehalose's role in modulating glucose metabolism and homeostasis.

Main Methods:

  • Review of existing studies on trehalose and glucose metabolism.
  • Analysis of molecular pathways influenced by trehalose.
  • Assessment of trehalose's impact on insulin sensitivity and hyperglycemia.

Main Results:

  • Trehalose demonstrates potential in modulating glucose metabolism.
  • Evidence suggests trehalose can stabilize glucose homeostasis.
  • Studies indicate trehalose influences at least 7 molecular pathways related to insulin sensitivity.

Conclusions:

  • Trehalose exhibits promising anti-hyperglycemic effects.
  • Trehalose may serve as a potent non-pharmacological agent for diabetes management.
  • Further research into trehalose for diabetes is warranted.
Keywords:
Diabetes mellitusGlucoseHomeostasisOxidative stressTrehalose

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