Related Experiment Video
Updated: Aug 18, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Central glucagon antagonizes morphine- and stress-induced antinociception in the mouse
D S Malcolm1, S Amir, J W Holaday
1Dept. of Medical Neurosciences, Walter Reed Army Inst. of Res., Washington, D.C. 20307-5100.
Abstract:
Previously, we have demonstrated that glucagon antagonizes morphine-induced antinociception in the rat (Malcolm et al. 1985). In the present studies we have shown that central injection of glucagon antagonizes morphine- and stress-induced antinociception in the mouse. Since stress-induced antinociception is mediated by the activation of endogenous opioid systems, these findings provide the first evidence for glucagon's ability to antagonize endogenous opioid actions.

