Related Experiment Video

Updated: Jan 22, 2026

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
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Negativation of PD-L1 Postoperatively in Initially Inoperable Stage III Non-Small Cell Lung Cancer Treated with

Fadi Nasr1,2,3, Ahmad Al Ghoche1, Roland Eid2

  • 1Hematology-Oncology Department, Mount Lebanon Hospital, Hazmieh, Lebanon.

Case Reports in Oncology
|June 28, 2019
PubMed

Insights

This study reports two cases of stage IIIA non-small cell lung cancer (NSCLC) where PD-L1 status became negative after immunotherapy, converting inoperable tumors to operable disease. Further research is needed to confirm if immunotherapy caused this PD-L1 negativation and operability conversion.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Research

Background:

  • Stage III non-small cell lung cancer (NSCLC) represents a critical stage between localized and metastatic disease.
  • Programmed death-ligand 1 (PD-L1) expression is increasingly important in lung cancer therapeutics.
  • Current treatment paradigms for stage IIIA NSCLC often involve complex multimodal approaches.

Observation:

  • Two patients with stage IIIA NSCLC, initially deemed inoperable, received immunotherapy-based treatments.
  • Both patients experienced a conversion to operable disease following treatment.
  • Postoperative assessment revealed a negativation of PD-L1 status in both cases.

Findings:

  • This is the first report of PD-L1 status negativation in stage IIIA NSCLC following immunotherapy.
  • Immunotherapy, in combination with chemotherapy or after progression, facilitated surgical conversion in these patients.
  • The observed PD-L1 negativation occurred in the postoperative setting.

Implications:

  • These findings suggest a potential role for immunotherapy in altering PD-L1 expression and enabling surgical resection in advanced NSCLC.
  • Further investigation is warranted to determine if immunotherapy directly causes PD-L1 negativation and facilitates operability.
  • Confirmation of these observations could significantly impact treatment strategies for stage IIIA NSCLC.
Keywords:
Non-small lung cancerPDL-1PDL-1 conversionPembrolizumab

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