Related Experiment Video
Updated: Jan 22, 2026
07:49
Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
Published on: February 20, 2020
9.9K
An update on the Lewis blood group system
1Technical Director of Immunohematology Reference Laboratory, Duke Hospital Transfusion Service.
Immunohematology
|June 28, 2019
Summary
This review details new findings on Lewis blood group antigens, including their role in disease susceptibility and bacterial interactions. It also covers Lewis antibodies causing transfusion reactions.
Area of Science:
- Immunology
- Genetics
- Transfusion Medicine
Background:
- The Lewis blood group system is crucial in transfusion medicine.
- Understanding Lewis antigens is vital for preventing transfusion reactions.
- Previous reviews have established the foundational knowledge of this system.
Purpose of the Study:
- To provide an update on the Lewis blood group system.
- To highlight new clinical significance of Lewis antigens.
- To report on recent cases of Lewis antibodies and their impact.
Main Methods:
- Literature review of recent studies on the Lewis blood group system.
- Analysis of clinical data regarding disease susceptibility and Lewis expression.
- Review of reported cases of hemolytic transfusion reactions.
Main Results:
- New information on Lewis antigen clinical significance, including disease susceptibility.
- Evidence suggesting a role for bacteria in Lewis antigen expression.
- Reported instances of Lewis antibodies causing hemolytic transfusion reactions.
- No new antigens identified; the total remains six (Lea, Leb, LebH, ALeb, BLeb, Leab).
Conclusions:
- The Lewis blood group system continues to evolve with new clinical insights.
- Lewis antigens are implicated in disease susceptibility and influenced by bacterial factors.
- Clinical vigilance for Lewis antibodies is necessary to prevent transfusion complications.
More Related Videos
Related Concept Videos
02:33Lewis Acids and Bases
48.2K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.2K
02:16Lewis Acids and Bases
16.8K
This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed, emphasizing the group 13 elements like boron or aluminium. Since group 13 elements possess three valence electrons, they form trivalent compounds with a sextet of electrons and a vacant orbital for the central atom. Consequently, these electron-deficient compounds accept electrons from other species to complete their octet in a chemical reaction. They...
16.8K
02:36Lewis Symbols and the Octet Rule
80.3K
Chemical bonds are complex interactions between two or more atoms or ions, which reduce the potential energy of the molecule. Gilbert N. Lewis developed a model called the Lewis model that simplified the depiction of chemical bond formation and provided straightforward explanations for the chemical bonds seen in most common compounds.
80.3K
02:46Covalent Bonding and Lewis Structures
60.8K
Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual attraction of atoms for a “shared” pair of electrons.
60.8K
02:54Lewis Structures of Molecular Compounds and Polyatomic Ions
44.9K
To draw Lewis structures for complicated molecules and molecular ions, it is helpful to follow a step-by-step procedure as outlined:
44.9K
02:19Lewis Structures and Formal Charges
21.2K
Lewis symbols can be used to indicate the formation of covalent bonds, which are shown in Lewis structures—drawings that describe the bonding in molecules and polyatomic ions. The periodic table can be used to predict the number of valence electrons in an atom and the number of bonds that will be formed to reach an octet. Group 18 elements, such as argon and helium, have filled electron configurations and thus rarely participate in chemical bonding. However, atoms from group 17, such as...
21.2K