Related Experiment Video

Updated: Jan 22, 2026

Transconjunctival Approach for Injection into the Rat Optic Nerve
02:33

Transconjunctival Approach for Injection into the Rat Optic Nerve

Published on: April 4, 2025

832

Current treatment of optic nerve gliomas

Marybeth K Farazdaghi1,2, William R Katowitz1,2, Robert A Avery1,2,3

  • 1Division of Ophthalmology, The Children's Hospital of Philadelphia.

Current Opinion in Ophthalmology
|June 28, 2019
PubMed
Abstract

Insights

Optic nerve gliomas (ONG) treatment is evolving. While chemotherapy is standard, targeted therapies show promise for these pediatric visual pathway tumors.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Ophthalmology

Background:

  • Optic pathway gliomas are low-grade neoplasms affecting the pediatric visual pathway.
  • They can be sporadic or associated with neurofibromatosis type 1.
  • Gliomas isolated to the optic nerve (ONG) have controversial treatment strategies.

Purpose of the Study:

  • To review current understanding of optic nerve glioma (ONG) treatments.
  • To highlight recent developments in ONG therapy.
  • To provide clinicians with an updated overview of available therapeutic options.

Main Methods:

  • Literature review focusing on ONG treatment.
  • Analysis of standard chemotherapy, molecularly targeted therapies, radiation, and surgery.
  • Synthesis of recent advancements and ongoing clinical studies.

Main Results:

  • Standard chemotherapy remains a primary treatment for ONG.
  • New molecularly targeted therapies, including MEK inhibitors and bevacizumab, are emerging.
  • Radiation therapy and surgical debulking are also discussed.

Conclusions:

  • Molecularly targeted therapies represent a promising new modality for ONG treatment.
  • Ongoing clinical studies are evaluating the efficacy of these novel agents.
  • A comprehensive understanding of evolving ONG therapies is crucial for clinical practice.

More Related Videos

A Surgical Approach for Optic Nerve Crush in a Rabbit Model06:15

A Surgical Approach for Optic Nerve Crush in a Rabbit Model

Published on: July 8, 2025

1.3K
Minimally-invasive Technique for Injection into Rat Optic Nerve07:34

Minimally-invasive Technique for Injection into Rat Optic Nerve

Published on: May 19, 2015

10.2K

Related Concept Videos

Electrical Current01:10

Electrical Current

Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
6.9K
Significance of Displacement Current01:27

Significance of Displacement Current

A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
5.8K
Current Trends in Nursing I01:28

Current Trends in Nursing I

Current trends in nursing include:
5.3K
Current Trends in Nursing II01:30

Current Trends in Nursing II

Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.4K
Charge and Current01:14

Charge and Current

Electric charge is the most fundamental quantity in an electric circuit. The effects of electric charge are encountered daily, such as when a wool sweater sticks to the human body or when a person receives a shock while walking on a carpet.
Charge is an inherent property of the atomic particles that make up matter and is measured in units called coulombs (C). Matter is composed of atoms, each consisting of electrons, protons, and neutrons. Electrons have a negative charge (-e), while protons...
5.2K
Current Dividers01:10

Current Dividers

In parallel electrical connections, resistors are linked between the same pair of nodes, creating an equal voltage across each resistor. Kirchhoff's current law is applied to these connections, establishing that the sum of currents through these resistors equals the source current. Utilizing Ohm's law, the source current is determined as the product of the source voltage and the sum of the reciprocals of individual resistances. This relationship simplifies the process of finding the current...
1.0K