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Updated: Jan 22, 2026
11:14
Primer-Free Aptamer Selection Using A Random DNA Library
Published on: July 26, 2010
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Number needed to treat: A primer for neurointerventionalists
Juan Carlos Martinez-Gutierrez1, Thabele Leslie-Mazwi2, Ronil V Chandra3
1Department of Neurology, Massachusetts General Hospital, Brigham and Women's Hospital, Boston, USA.
Summary
The number needed to treat (NNT) helps evaluate stroke therapies. Mechanical thrombectomy is the most effective acute intervention for large-vessel occlusions, offering significant patient benefit.
Area of Science:
- Neurointerventional practice
- Clinical trial analysis
- Health economics
Background:
- The number needed to treat (NNT) is a key metric in neurointerventional practice.
- NNT quantifies the number of patients requiring treatment for one to benefit.
- Understanding NNT is crucial for interpreting study results in clinical practice.
Purpose of the Study:
- To review the theory, calculation, and application of NNT in stroke interventions.
- To demonstrate NNT calculation methods using recent thrombectomy trial data.
- To provide a comparative analysis of NNT across various stroke therapies.
Main Methods:
- Review of NNT principles and stroke intervention literature.
- Calculation of NNT using data from mechanical thrombectomy trials.
- Comparative analysis of NNT for mechanical thrombectomy, tPA, carotid endarterectomy, antiplatelet, and statin therapies.
Main Results:
- Mechanical thrombectomy shows the highest efficacy among acute stroke interventions for emergent large-vessel occlusions.
- NNT provides a universal metric for comparing diverse stroke treatment strategies.
- Comparative NNT values highlight the effectiveness of mechanical thrombectomy.
Conclusions:
- NNT aids in understanding clinical trial data for stroke therapies.
- NNT assists in prioritizing healthcare resources for stroke treatment.
- Effective use of NNT improves communication among stakeholders regarding stroke interventions.
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