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[Association between DIO polymorphism and aerobic endurance].

Wen Ting Zhou1,2, Yang Hu3

  • 1Zunyi Normal University, Zunyi 563006.

Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology
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Summary

Genetic variations in iodothyronine deiodinase (DIO) genes are linked to endurance exercise capacity. Specific DIO gene haplotypes, particularly CT, show associations with aerobic endurance performance in elite male and female athletes.

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Area of Science:

  • Genetics
  • Exercise Physiology
  • Sports Science

Background:

  • Endurance exercise capacity is influenced by various genetic factors.
  • Polymorphisms in iodothyronine deiodinase (DIO) genes, specifically DIO1 and DIO2, are investigated for their role in athletic performance.
  • The TSHR gene is also considered for its potential as a genetic marker for aerobic endurance.

Purpose of the Study:

  • To investigate the association between polymorphisms in the iodothyronine deiodinase (DIO) gene region and endurance exercise capacity.
  • To determine if the TSHR gene can serve as a genetic marker for aerobic endurance performance.

Main Methods:

  • Genotyping of three single nucleotide polymorphisms (SNPs): C785T (DIO1), Thr92Ala (DIO2), and Gly3Asp (DIO2) was performed.
  • Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) was used to analyze genotypes in 123 elite long-distance runners (EEA) and 127 college students (CG) from northern China.
  • Athletes were further categorized by sport level (international masters, masters) and event type (5/10 km, marathon).

Main Results:

  • No significant differences were found for C785T (DIO1) and Thr92Ala (DIO2) loci between elite athletes and controls.
  • The Gly3Asp (DIO2) locus showed significant differences in genotype frequency between controls and international masters, and between controls and marathon runners.
  • Strong linkage disequilibrium was observed between Thr92Ala and Gly3Asp loci of the DIO2 gene.
  • Haplotype CT frequencies differed significantly between sexes and between controls and male elite athletes, particularly in masters and marathon runners.
  • Haplotype TC frequencies were higher in female international masters and 5000m/10000m runners compared to female controls.

Conclusions:

  • The study identified specific DIO gene haplotypes associated with aerobic endurance performance.
  • Haplotype CT in DIO2 gene may serve as a genetic marker for aerobic endurance in male elite long-distance runners, especially masters and marathon athletes.
  • Haplotype CT is also linked to aerobic endurance in female elite long-distance runners, particularly international masters and 5000m/10000m athletes.