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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Right Ventricular Involution: Big Changes in Small Hearts

Megan E Bowen1, Craig H Selzman1, Stephen H McKellar1

  • 1University of Utah, School of Medicine, Salt Lake City, Utah; Division of Cardiothoracic Surgery, Department of Surgery, Salt Lake City, Utah.

The Journal of Surgical Research
|June 29, 2019
PubMed

Insights

The fetal right ventricle (RV) is a model of compensated hypertrophy. Understanding its adaptation to pulmonary circulation may reveal new therapies for RV failure.

Area of Science:

  • Cardiovascular Physiology
  • Developmental Biology

Background:

  • The fetal right ventricle (RV) functions as the systemic pump, with thickness comparable to the left ventricle (LV).
  • Postnatally, the RV adapts to the lower-pressure pulmonary circulation, elongating without significant wall thickening.

Purpose of the Study:

  • To investigate the fetal RV as a model of compensated RV hypertrophy.
  • To identify potential therapeutic strategies for RV failure by understanding RV adaptation processes.

Main Methods:

  • A comprehensive literature review was conducted.
  • Pertinent articles published from 1980 to the present were identified and analyzed.

Main Results:

  • Key topics in right ventricular involution include morphologic and histologic changes.
  • Cellular proliferation, terminal differentiation, stress effects, excitation-contraction coupling, and apoptosis during RV development were identified.
  • Literature shows variability in results, often due to differences in animal models.

Conclusions:

  • The RV undergoes significant multi-level changes transitioning from systemic to pulmonary circulation.
  • Despite variable findings, a clear need for further research in RV adaptation is evident.
Abstract

Keywords:
Heart remodelingNeonatal cardiac developmentPostnatal cardiac developmentRight ventricular involutionRight ventricular remodeling

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