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Updated: Jan 22, 2026
13:51
Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
Published on: November 10, 2017
15.8K
Hybrid drug nanocrystals.
Yi Lu1, Yongjiu Lv2, Tonglei Li3
1Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.
Advanced Drug Delivery Reviews
|June 30, 2019
Summary
Hybrid nanocrystals embed imaging agents for drug delivery, enabling simultaneous therapy and bioimaging. This technique allows detailed study of drug pharmacokinetics and dissolution within the body.
Area of Science:
- Pharmaceutical Sciences
- Biomedical Engineering
- Materials Science
Background:
- Nanocrystals are promising for delivering poorly water-soluble drugs, but their in vivo behavior is not fully understood.
- Traditional nanocrystallization focuses on drug dissolution enhancement.
- The dying crystal phenomenon led to hybrid nanocrystals for improved drug delivery and imaging.
Purpose of the Study:
- To introduce the hybrid nanocrystal technique for drug delivery and bioimaging.
- To discuss the preparation, theoretical concepts, and applications of hybrid nanocrystals.
- To highlight advancements in self-discriminative hybrid nanocrystals using environment-responsive probes.
Main Methods:
- Embedding fluorophores into the crystal lattice of drug nanocrystals.
- Utilizing the dying crystal phenomenon to create hybrid structures.
- Developing environment-responsive probes for self-discriminative nanocrystals.
Main Results:
- Hybrid nanocrystals enable concurrent therapy and in vivo bioimaging.
- This approach facilitates the study of pharmacokinetics and nanocrystal dissolution.
- Nanocrystals demonstrate long-term durability for biological interactions.
Conclusions:
- Hybrid nanocrystal technology offers a powerful tool for theranostic drug delivery.
- Further development is expected to advance nanocrystal-based theranostic strategies.
- This technique enhances understanding and application of nanocrystal drug delivery systems.
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