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Updated: Jan 22, 2026

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer
Published on: June 13, 2019
Prostatic Stromal Tumors of Uncertain Malignant Potential
Joon Yau Leong1, Thenappan Chandrasekar1, Christopher Sebastiano2
1Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.
Abstract:
We present a 53-year-old man with a multilocular solid and cystic mass measuring 19 cm on cross-sectional imaging. After undergoing pelvic mass excision, final histopathology confirmed the diagnosis of primary prostatic stromal tumor of uncertain malignant potential (STUMP). Prostatic STUMPs are rare mesenchymal tumors with diverse histologic patterns. They are distinct from prostatic stromal sarcomas as they do not behave aggressively, although some may occasionally demonstrate local recurrence after resection. Due to their unpredictable malignant potential, lack of correlation between histologic patterns, and sarcomatous differentiation, these patients warrant surgical excision and close follow-up.
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