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Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition
Published on: August 18, 2023
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Increased Intracranial Pressure Damages Optic Nerve Structural Support
Lauren East1, Matthew Lyon2,3, Parth Agrawal1
1Medical College of Georgia, Augusta University, Augusta, Georgia.
Journal of Neurotrauma
|July 2, 2019
Summary
Elevated intracranial pressure (ICP) increases porosity in optic nerve sheath (ONS) trabecular fibers immediately and 30 days later. This structural change in ONS fibers suggests a link between ICP and ONS tissue.
Area of Science:
- Ophthalmology
- Neuroscience
- Biomedical Engineering
Background:
- Optic nerve sheath diameter (ONSD) is a clinical indicator for elevated intracranial pressure (ICP).
- The structural integrity of the optic nerve sheath (ONS) under increased ICP is not fully understood.
Purpose of the Study:
- To examine the immediate impact of ICP-induced ONS dilation on trabecular fibers.
- To assess changes in these fibers 30 days after ICP elevation.
Main Methods:
- A swine model was used to induce elevated ICP via epidural balloon inflation.
- Scanning electron microscopy analyzed ONS porosity in control and experimental groups (immediate and 30-day delayed measurement).
Main Results:
- Experimental groups showed significantly higher ONS porosity compared to controls (IM p=0.0018; DM p=0.0092).
- No significant difference in porosity was found between immediate and 30-day delayed measurements (p=0.9485).
- Increased ICP leads to more porous ONS trabecular fibers.
Conclusions:
- Elevated ICP causes immediate and persistent structural changes (increased porosity) in ONS trabecular fibers.
- These findings suggest a direct link between ICP and ONS tissue remodeling.
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