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Mood Effects After Deep Brain Stimulation for Parkinson's Disease: An Update
Ettore A Accolla1, Claudio Pollo2
1Neurology Unit, Department of Medicine, HFR - Hôpital Cantonal Fribourg and Fribourg University, Fribourg, Switzerland.
Frontiers in Neurology
|July 2, 2019
Summary
Deep brain stimulation (DBS) can improve Parkinson's Disease (PD) motor symptoms, but its impact on depression is variable. Both subthalamic nucleus (STN) and globus pallidus (GPi) targets show benefits for mood in PD patients.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Depression is a common and debilitating symptom in Parkinson's Disease (PD).
- Deep brain stimulation (DBS) improves motor function in PD, but its effects on mood are unpredictable.
- Understanding the neuropsychiatric outcomes of DBS is crucial for patient well-being.
Purpose of the Study:
- To review the evidence on mood effects following DBS targeting the subthalamic nucleus (STN) or globus pallidus pars interna (GPi) in Parkinson's Disease.
- To identify factors influencing neuropsychiatric outcomes after DBS surgery for PD.
Main Methods:
- Systematic review of existing literature on DBS for Parkinson's Disease and its impact on mood.
- Analysis of studies comparing STN-DBS and GPi-DBS regarding depression symptoms.
Main Results:
- Both STN and GPi DBS demonstrated a favorable profile for improving depression symptoms in PD patients.
- No consistent advantage of one target over the other was found for mood improvement.
- Factors such as presurgical psychosocial status, postsurgical coping, and medication changes influence mood outcomes.
Conclusions:
- DBS is a viable option for managing both motor and mood symptoms in Parkinson's Disease.
- Target selection (STN vs. GPi) may be guided by individual patient characteristics and anatomical considerations.
- Further research and technological advancements are needed to refine DBS targeting for optimal neuropsychiatric outcomes in PD.