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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Age-Specific Reference Ranges for Serum Prostate-Specific Antigen in Puerto Rican Men with Proven Prostate Cancer
Ernesto P Esteban1, Adalis Rivera2, Jaileen Rivera-Rodriguez2
1Physics Department, University of Puerto Rico, Humacao.
Puerto Rico Health Sciences Journal
|July 2, 2019
Summary
This study analyzed prostate-specific antigen (PSA) levels in Puerto Rican men with prostate cancer (PC), establishing new age-specific PSA reference ranges to enhance PC diagnosis and treatment.
Area of Science:
- Urology
- Oncology
- Biostatistics
Background:
- Prostate cancer (PC) diagnosis relies heavily on prostate-specific antigen (PSA) levels.
- Establishing accurate, population-specific reference ranges for PSA is crucial for effective PC management.
Purpose of the Study:
- To conduct the first statistical study of PSA levels in Puerto Rican men diagnosed with PC.
- To propose novel age-specific PSA reference ranges to improve PC diagnosis and prognosis.
Main Methods:
- A statistical analysis of PSA levels was performed on a cohort of 16,305 Puerto Rican men with proven PC.
- Data were collected between 2004 and 2012.
- Central measures and variability of PSA levels were determined, including mean, median, mode, index of dispersion (ID), and interquartile range (IQR).
Main Results:
- Significant variability in PSA data was observed, indicated by ID values (3.1 ng/mL) and over-dispersion shown by IQR values (11.3 ng/mL).
- Median age-specific PSA reference ranges and confidence intervals (CI) were determined for Puerto Rican men with PC.
- Median PSA levels and CIs were also established for two specific ranges: (0
Conclusions:
- The study successfully conducted a comprehensive statistical analysis of PSA levels in Puerto Rican men with PC.
- Two new age-specific PSA reference ranges were developed to aid in clinical decision-making and treatment strategies for prostate cancer.
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