Related Experiment Video
Updated: Jan 22, 2026

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats
Published on: June 18, 2018
Chronic Pruritus Responding to Dupilumab-A Case Series
Lisa L Zhai1,2, Kevin T Savage3, Connie C Qiu4,5
1Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Background:
Chronic pruritus is defined as itch lasting for greater than six weeks. Pruritus is a burdensome manifestation of several internal and external disease states with a significant impact on quality of life. Dupilumab has shown promise in treating a number of conditions including atopic dermatitis (AD) and asthma. Its success in reducing pruritus in AD has generated interest regarding its potential application in other pruritic conditions, such as chronic pruritus of unknown origin, uremic pruritus, and pruigo nodularis.
Methods:
In this retrospective analysis, we present a series of 20 recalcitrant pruritus patients seen at a tertiary center treated with off-label dupilumab at standard AD dosing.
Results:
Dupilumab was successful at reducing itch in all treated patients, leading to complete resolution in 12/20 patients and an overall mean NRSi reduction of 7.55. Dupilumab was well tolerated with no significant adverse effects.
Conclusions:
Our case series suggests dupilumab may be a safe and efficacious therapeutic option in several pruritic conditions and demonstrates the need for further studies to better ascertain its place in the pruritus treatment armamentarium.
Related Concept Videos
Resistors In Series
In a series circuit, the...
Series Resonance
Trigonometric Fourier series
The trigonometric Fourier series specifically expresses a periodic function with a defined period T using sine...
Convergence of Fourier Series
The Gibbs phenomenon refers to the persistent oscillations and overshoots that occur near discontinuities...
Series R—L Circuit Transients
Using Kirchhoff's Voltage Law (KVL) to analyze this circuit helps determine the total asymmetrical fault current, which consists...
Series and Parallel Capacitors
First, consider capacitors connected in series to a battery. In this configuration, the plate connected to the battery's positive terminal develops a positive charge, while the plate attached to the negative terminal becomes negatively charged. An equal magnitude of charge is induced on the...

